"When I reviewed the Synapse 19, I wrote, “As long as you tend to travel light, and you’ve got a 13-inch (or smaller) laptop, this is a superb, and superbly versatile, bag.” With the Synapse 25, those caveats no longer apply: It’s just a superb, versatile bag. The Synapse 19 is still my everyday bag, because I like to travel light and its smaller size forces me to do so. But I have to admit that I’m envious of the Synapse 25. It’s a little bit more of everything that’s great about the 19, and the Cache/rails system is fantastic. The 25 is one of the most versatile bags I’ve seen, and though it’s not inexpensive, my experience with its smaller sibling—four years of heavy use and still going strong—suggests that you’re getting what you pay for."