I have fibromyalgia, and will never be able to carry a large bag on my back or over the shoulder when I travel. I have ordered a Synapse (yay!), and my guess is that it will be the largest backpack I'm ever comfortable carrying for any length of time.
I would love an Aeronaut, and I could load one up and pick it up to carry a few feet, but walking with it longer than a few minutes would cause me great pain. Traipsing through an airport with one would be impossible without great pain and fatigue that would last well over a day (fibro is great fun, lemme tell ya, but it certainly isn't the worst thing to have).
Will Tom Bihn ever make a carry-on bag that has wheels, for those of us who can't hoist heavy loads long distance? :)
Anyone else struggle with this? Have you ever bought one of those portable wheeled travel racks to use with a non-wheeled bag? Does that work?