I bought a Synapse and used it for several weeks. It's a great bag, and while I really like it a lot, I ended up giving it to my wife. I'm back to using my Brain Bag. She's been using the Synapse to go back and forth to work -- carrying several books, a journal, folders, a large thermos, ipod, portable speaker system for the ipod, her purse, pens, and quite a few other odds and ends that don't appear in the picture above. She likes backpacks but, at 5'2", she often feels like they look way too big on her. The Synapse is perfect -- and it can carry everything she needs (there was still plenty of unused space with all these things inside).