I used to carry the same bag every day, day in, day out. Now I alternate between the Synapse and the Large Cafe Bag. Instead of combing through pockets to transfer small items, I've taken to putting must-haves in the Kit and just transferring that. All I have to remember is reading glasses and sunglasses.
Current Kit contents: emergency cash, nail clipper, cough drops, toothpick, hand balm, small pouch (MetroCard), pen, notepad.
In addition, when I take an exercise class, I empty my pockets (cash, keys) into the Kit and add my wristwatch.
The ballistic-nylon Kit feels better to handle than a pouch.